Ndevahoma, Fransina2022-05-242022-05-242021-02Ndevahoma, F. (2021). Iron metabolism and its association with chronic inflammation and cardiovascular risk in Type 2 diabetes mellitus. (Unpublished masters's thesis). Namibia University of Science and Technology, Windhoek.http://ir.nust.na:8080/jspui/handle/10628/875Thesis presented in fulfilment of the requirements for the degree of Master of Health Sciences, Faculty of Health and Applied Sciences, Namibia University of Science and Technology, Windhoek, Namibia.Type 2 diabetes mellitus (T2D) is a low‐grade systemic inflammatory condition that is characterised by hyperglycaemia driven by defects in insulin resistance, insulin secretion, or both. Hyperglycaemia, obesity‐induced inflammation, and dyslipidaemia have been implicated in increasing cardiovascular risk in patients with T2D. Interestingly, a growing body of evidence has also linked these abnormalities to altered iron metabolism in patients with T2D. However, the exact mechanisms behind this dysregulation are not well understood. Therefore, understanding the iron profiles in poor glucose control may pave ways to the identification of pathways involved in iron dysmetabolism and the development of therapeutic interventions. Therefore, the primary aim of this study was to investigate iron profiles in patients with T2D and to further assess the impact of inflammation on these profiles. In addition, it aimed to assess the cardiovascular risk in patients with T2D and to determine whether there are any associations between iron lipids and inflammation profiles in these patients.enType 2 diabetesInflammationIron metabolismCardiovascular riskObesityThesis