Investigating TH2‐mediated immune response in children with type 1 hypersensitivity.
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Date
2022-02
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Namibia University of Science and Technology
Abstract
The global prevalence of type 1 hypersensitivity is becoming more prevalent in recent years,
particularly among children in developing countries. This has been attributed to rapid modernisation
in low‐to‐middle income countries which promotes the manifestation of allergy risk factors. Type 1
hypersensitivity reactions are exaggerated immune responses to allergens that would not usually elicit
immunological response. These allergic reactions are primarily characterized by T helper (TH2)‐
mediated inflammation modulated by interleukin (IL)‐4, a cytokine that promotes B‐cell activation and
class switch to secrete immunoglobin (Ig)E. Notably, the severity of TH2‐mediated inflammation in
allergic reactions seems to be influenced by the type of allergen. Therefore, this study aimed to
evaluate TH2 immune responses in children with atopy.
Description
Thesis presented in fulfilment of the requirements for the degree of Master of Health Sciences,
Faculty of Health and Applied Sciences, Namibia University of Science and Technology, Windhoek,
Namibia.
Keywords
Allergy, Allergen, Immunoglobulin E, Interleukin 4, Type 1 hypersensitivity, T helper 2 cell
Citation
Nepolo, E. P. (2022). Investigating TH2‐mediated immune response in children with type 1 hypersensitivity. (Unpublished master's thesis). Namibia University of Science and Technology, Windhoek.