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dc.contributor.authorNepolo, Elina Penomwaameni-
dc.identifier.citationNepolo, E. P. (2022). Investigating TH2‐mediated immune response in children with type 1 hypersensitivity. (Unpublished master's thesis). Namibia University of Science and Technology, Windhoek.en_US
dc.descriptionThesis presented in fulfilment of the requirements for the degree of Master of Health Sciences, Faculty of Health and Applied Sciences, Namibia University of Science and Technology, Windhoek, Namibia.en_US
dc.description.abstractThe global prevalence of type 1 hypersensitivity is becoming more prevalent in recent years, particularly among children in developing countries. This has been attributed to rapid modernisation in low‐to‐middle income countries which promotes the manifestation of allergy risk factors. Type 1 hypersensitivity reactions are exaggerated immune responses to allergens that would not usually elicit immunological response. These allergic reactions are primarily characterized by T helper (TH2)‐ mediated inflammation modulated by interleukin (IL)‐4, a cytokine that promotes B‐cell activation and class switch to secrete immunoglobin (Ig)E. Notably, the severity of TH2‐mediated inflammation in allergic reactions seems to be influenced by the type of allergen. Therefore, this study aimed to evaluate TH2 immune responses in children with atopy.en_US
dc.publisherNamibia University of Science and Technologyen_US
dc.subjectImmunoglobulin Een_US
dc.subjectInterleukin 4en_US
dc.subjectType 1 hypersensitivityen_US
dc.subjectT helper 2 cellen_US
dc.titleInvestigating TH2‐mediated immune response in children with type 1 hypersensitivity.en_US
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