Foreign Direct Investment (FDI) constitutes a resource flow which is widely considered particularly useful for the economic development of developing countries. This resource has however, proved elusive for countries in Africa, despite widespread moves to liberalise investment regimes and offer attractive incentives. This paper reviews the determinants of FDI in the light of empirical evidence and using Zambia as a case study. Using Dunning's Eclectic Paradigm as an analytic framework, the paper shows that there are location specific variables which tend to constrain the inward flow of FDI into Zambia